Dmochowski Group


Research in the Dmochowski lab encompasses many areas of Bioinorganic, Bioorganic, and Biophysical Chemistry, as well as Chemical Biology. Our lab is comprised of people with backgrounds spanning these disciplines. We are developing small molecules, proteins, and spectroscopic techniques for studying complex biomolecular systems. Our approach involves cycles of molecular design, synthesis, and measurement.

Recent Publications

  • B.W. Roose, S.D. Zemerov, Y. Wang, M. Kasimova, V. Carnevale, I.J. Dmochowski, A structural basis for Xe-129 Hyper-CEST signal in TEM-1 β-lactamase, ChemPhysChem, 19, 1-9, 2018. DOI: 10.1002/cphc.201800624. Cover feature. Highlighted in ChemistryViews.
  • K.W. Pulsipher, J.A. Bulos, J.A. Villegas, J.G. Saven, I.J. Dmochowski, A protein-protein host-guest complex: Thermostable ferritin encapsulatingpositively supercharged green fluorescent protein, Prot. Sci., 27, 1755-1766, 2018. PMID: 30051936, DOI: 10.1002/pro.3483.
  • Zemerov, S.; Roose, B.; Greenberg, M.; Wang, Y.; Dmochowski, I. Cryptophane nanoscale assemblies expand Xe-129 NMR biosensing. Anal. Chem., 90(12), 7730-7738, 2018. PMCID: PMC6050516, DOI: 10.1021/acs.analchem.8b01630.
  • Rapp, T.; Highley, C.; Manor, B.; Burdick, J.; Dmochowski, I. Ruthenium-crosslinked hydrogels with rapid, visible-light degradation. Chemistry-Eur. J., 24(10), 2328-2333, 2018. PMCID: PMC5915374.

Group News

January 2019

November 2018

  • Congrats to Dr. Sean Yeldell on his successful dissertation defense, titled Next-generation oligonucleotide probes for Transcriptome In Vivo Analysis (TIVA).

July 2018

  • Congratulations to Dr. Ben Roose for successfully defending his dissertation, titled Genetically Encoded Contrast Agents for Hyperpolarized Xenon NMR.

June 2018

  • Congratulations to Dr. Teresa Rapp on her successful dissertation defense, titled Synthesis and Characterization of Photolabile Ruthenium Polypyridyl Crosslinkers with Applications in Soft Materials and Biology.