Dmochowski Group

Welcome!

Research in the Dmochowski lab encompasses many areas of Bioinorganic, Bioorganic, and Biophysical Chemistry, as well as Chemical Biology. Our lab is comprised of people with backgrounds spanning these disciplines. We are developing small molecules, proteins, and spectroscopic techniques for studying complex biomolecular systems. Our approach involves cycles of molecular design, synthesis, and measurement.

Group_summer2017

Recent Publications

Yeldell, S.; Ruble, B.; Dmochowski, I. Oligonucleotide modifications enhance probe stability for single cell transcriptome in vivo analysis (TIVA). Org. Biomol. Chem. 2017.

Riggle, B. A.; Greenberg, M.; Wang, Y.; Wissner, R. F.; Zemerov, S.; Petersson, J.; Dmochowski, I. A cryptophane-based “turn-on” 129Xe NMR biosensor for monitoring calmodulin. Org. Biomol. Chem. 2017.

Roose, B. W.; Zemerov, S. D.; Dmochowski, I. J. Nanomolar small-molecule detection using a genetically encoded 129Xe NMR contrast agent. Chem. Sci. 2017.


Group News


October
  • Sean and Brittani's paper "Oligonucleotide modifications enhance probe stability for single cell transcriptome in vivo analysis (TIVA)" published in Org. Biomol. Chem. DOI: 10.1039/C7OB02353G
  • Brittany, Mara, Yanfei, and Serge's paper "A cryptophane-based 'turn-on' Xe-129 NMR biosensor for monitoring calmodulin" published in Org. Biomol. Chem. DOI: 10.1039/C7OB02391J

September

  • Ben and Serge's paper "Nanomolar small-molecule detection using a genetically encoded Xe-129 contrast agent" is published in Chem. Sci. DOI: 10.1039/C7SC03601A

August

  • Katie's collaborative work incorporating ferritin into graphene-based electrodes featured in Penn News. View article

April
  • Congratulations to Dr. Katie Pulsipher for successfully defending her dissertation, titled Thermophilic Ferritin: Versatile Nanohost.

March

  • Senior undergraduate Jordan Doman receives a Hertz fellowship and NSF fellowship for graduate school. More information about the Hertz fellowship can be found at http://hertzfoundation.org/default.aspx.
  • Group alum Dr. Yanfei Wang receives an "Outstanding Students Abroad" award from the Chinese Government. More information can be found at http://www.csc.edu.cn/chuguo/s/596.

November

  • Sean wins the annual Pop Talks competition for his excellent presentation of his light-activated oligonucleotide work!
  • Teresa's paper "Kinetics and Photochemistry of Ruthenium Bisbipyridine Diacetonitrile Complexes: An Interdisciplinary Inorganic and Physical Chemistry Laboratory Exercise" is published in J. Chem Educ.
August